William McCoull : rechercher sur Z-Library

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1

Identification and optimisation of 7-azaindole PAK1 inhibitors with improved potency and kinase selectivity

McCoull, William, Hennessy, Edward J., Blades, Kevin, Box, Matthew R., Chuaqui, Claudio, Dowling, James E., Davies, Christopher D., Ferguson, Andrew D., Goldberg, Frederick W., Howe, Nicholas J., Kemm

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 527 KB

english, 2014

2

ChemInform Abstract: Asymmetric Synthesis of Aziridine 2-Phosphonates and Azirinyl Phosphonates from Enantiopure Sulfinimines.

Franklin A. Davis, William McCoull

Journal:

Année:

1999

Fichier:

PDF, 33 KB

1999

3

ChemInform Abstract: Recent Synthetic Applications of Chiral Aziridines

William McCoull, Franklin A. Davis

Journal:

Année:

2000

Fichier:

PDF, 24 KB

2000

4

ChemInform Abstract: 2H-Azirine 3-Phosphonates: A New Class of Chiral Iminodienophiles. Asymmetric Synthesis of Quaternary Piperidine Phosphonates.

Franklin A. Davis, Yongzhong Wu, Hongxing Yan, Kavirayani R. Prasad, William McCoull

Journal:

Année:

2002

Fichier:

PDF, 32 KB

2002

5

Asymmetric Synthesis of Aziridine 2-Phosphonates from Enantiopure Sulfinimines (N-Sulfinyl Imines). Synthesis of α-Amino Phosphonates.

Franklin A. Davis, Yongzhong Wu, Hongxing Yan, William McCoull, Kavirayani R. Prasad

Journal:

Année:

2003

Fichier:

PDF, 211 KB

2003

6

Novel thienopyrimidine and thiazolopyrimidine kinase inhibitors with activity against Tie-2 in vitro and in vivo

Richard W.A. Luke, Peter Ballard, David Buttar, Leonie Campbell, Jon Curwen, Steve C. Emery, Alison M. Griffen, Lorraine Hassall, Barry R. Hayter, Cliff D. Jones, William McCoull, Martine Mellor, Mike

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 851 KB

english, 2009

7

Diels-alder reaction on solid supports using polymer-bound oxazolidinones

Jeffrey D. Winkler, William McCoull

Journal:

Tetrahedron Letters

Année:

1998

Langue:

english

Fichier:

PDF, 172 KB

english, 1998

8

Asymmetric synthesis of aziridine 2-phosphonates and azirinyl phosphonates from enantiopure sulfinimines

Franklin A. Davis, William McCoull

Journal:

Tetrahedron Letters

Année:

1999

Langue:

english

Fichier:

PDF, 266 KB

english, 1999

9

Design and synthesis of novel monocyclic β-lactam inhibitors of prostate specific antigen

Robert M. Adlington, Jack E. Baldwin, Beining Chen, Stephen L. Cooper, William McCoull, Gareth J. Pritchard, Trevor J. Howe, Gerald W. Becker, Robert B. Hermann, Ann M. McNulty, Blake L. Neubauer

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1997

Langue:

english

Fichier:

PDF, 316 KB

english, 1997

10

Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes

William McCoull, Matthew S. Addie, Alan M. Birch, Susan Birtles, Linda K. Buckett, Roger J. Butlin, Suzanne S. Bowker, Scott Boyd, Stephen Chapman, Robert D.M. Davies, Craig S. Donald, Clive P. Green,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 1.09 MB

english, 2012

11

Discovery of a Potent, Selective, and Orally Bioavailable Acidic 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitor: Discovery of 2-[(3 S )-1-[5-(Cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic Acid (AZD4017)

Scott, James S., Bowker, Suzanne S., deSchoolmeester, Joanne, Gerhardt, Stefan, Hargreaves, David, Kilgour, Elaine, Lloyd, Adele, Mayers, Rachel M., McCoull, William, Newcombe, Nicholas J., Ogg, Derek

Journal:

Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 2.01 MB

english, 2012

12

ChemInform Abstract: Identification, Optimization and in vivo Evaluation of Oxadiazole DGAT-1 Inhibitors for the Treatment of Obesity and Diabetes.

William McCoull, et al. et al.

Journal:

Année:

2012

Fichier:

PDF, 27 KB

2012

13

Design, Synthesis, and Proposed Active Site Binding Analysis of Monocyclic 2-Azetidinone Inhibitors of Prostate Specific Antigen

Adlington, Robert M., Baldwin, Jack E., Becker, Gerald W., Chen, Beining, Cheng, Leifeng, Cooper, Stephen L., Hermann, Robert B., Howe, Trevor J., McCoull, William, McNulty, Ann M., Neubauer, Blake L.

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 664 KB

english, 2001

14

Identification of pyrazolo-pyrimidinones as GHS-R1a antagonists and inverse agonists for the treatment of obesity

McCoull, William, Barton, Peter, Broo, Anders, Brown, Alastair J. H., Clarke, David S., Coope, Gareth, Davies, Robert D. M., Dossetter, Alexander G., Kelly, Elizabeth E., Knerr, Laurent, MacFaul, Phil

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 374 KB

english, 2013

15

Experimental Testing of Quantum Mechanical Predictions of Mutagenicity: Aminopyrazoles

Leach, Andrew G., McCoull, William, Bailey, Andrew, Barton, Peter, Mee, Christine, Rosevere, Eleanor

Journal:

Chemical Research in Toxicology

Année:

2013

Langue:

english

Fichier:

PDF, 1.64 MB

english, 2013

16

2 H -Azirine 3-Phosphonates: A New Class of Chiral Iminodienophiles. Asymmetric Synthesis of Quaternary Piperidine Phosphonates

Davis, Franklin A., Wu, Yongzhong, Yan, Hongxing, Prasad, Kavirayani R., McCoull, William

Journal:

Organic Letters

Année:

2002

Langue:

english

Fichier:

PDF, 53 KB

english, 2002

17

Concise Asymmetric Synthesis of α-Amino Acid Derivatives from N -Sulfinylimino Esters

Davis, Franklin A., McCoull, William

Journal:

Journal of Organic Chemistry

Année:

1999

Langue:

english

Fichier:

PDF, 37 KB

english, 1999

18

Asymmetric Synthesis of α-Methylphosphophenylalanine Derivatives Using Sulfinimine-Derived Enantiopure Aziridine-2-phosphonates

Davis, Franklin A., McCoull, William, Titus, Donald D.

Journal:

Organic Letters

Année:

1999

Langue:

english

Fichier:

PDF, 43 KB

english, 1999

19

Asymmetric Synthesis of Aziridine 2-Phosphonates from Enantiopure Sulfinimines ( N -Sulfinyl Imines). Synthesis of α-Amino Phosphonates

Davis, Franklin A., Wu, Yongzhong, Yan, Hongxing, McCoull, William, Prasad, Kavirayani R.

Journal:

Journal of Organic Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 191 KB

english, 2003

20

Identification, Optimization, and Pharmacology of Acylurea GHS-R1a Inverse Agonists

McCoull, William, Barton, Peter, Brown, Alastair J. H., Bowker, Suzanne S., Cameron, Jennifer, Clarke, David S., Davies, Robert D. M., Dossetter, Alexander G., Ertan, Anne, Fenwick, Mark, Green, Clive

Journal:

Journal of Medicinal Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 843 KB

english, 2014

21

8-Substituted Analogues of 3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl- adenine: Highly Potent and Selective PDE4 Inhibitors

Whitehead, John W. F., Lee, Gary P., Gharagozloo, Parviz, Hofer, Peter, Gehrig, André, Wintergerst, Peter, Smyth, Donald, McCoull, William, Hachicha, Mohamed, Patel, Aniket, Kyle, Donald J.

Journal:

Journal of Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 108 KB

english, 2005

22

Synthesis of 3-(Hetero)aryl Tetrahydropyrazolo[3,4- c ]pyridines by Suzuki–Miyaura Cross-Coupling Methodology

Kemmitt, Paul D., Blades, Kevin, Box, Matthew R., Dickinson, Stephanie, Lamont, Gillian M., Madden, Katrina, McCoull, William, Williams, Jason

Journal:

Journal of Organic Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 823 KB

english, 2014

23

A study of the intramolecular stille cross coupling reaction of vinylstannyl chloroformates: application to the synthesis of ?-methylene lactones

Adlington, Robert M., Baldwin, Jack E., Gans�uer, Andreas, McCoull, William, Russell, Andrew T.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Année:

1994

Langue:

english

Fichier:

PDF, 711 KB

english, 1994

24

Recent Synthetic Applications of Chiral Aziridines

McCoull, William, Davis, Franklin A.

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 1.66 MB

english, 2000

25

ChemInform Abstract: Synthesis of 3-(Hetero)aryl Tetrahydropyrazolo[3,4-c]pyridines by Suzuki-Miyaura Cross-Coupling Methodology.

Kemmitt, Paul D., Blades, Kevin, Box, Matthew R., Dickinson, Stephanie, Lamont, Gillian M., Madden, Katrina, McCoull, William, Williams, Jason

Journal:

Année:

2015

Fichier:

PDF, 18 KB

2015

26

Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors

McCoull, William, Hennessy, Edward J., Blades, Kevin, Chuaqui, Claudio, Dowling, James E., Ferguson, Andrew D., Goldberg, Frederick W., Howe, Nicholas, Jones, Christopher R., Kemmitt, Paul D., Lamont,

Journal:

ACS Medicinal Chemistry Letters

Année:

2016

Langue:

english

Fichier:

PDF, 441 KB

english, 2016

27

Indazole-6-phenylcyclopropylcarboxylic Acids as Selective GPR120 Agonists with in Vivo Efficacy

McCoull, William, Bailey, Andrew, Barton, Peter, Birch, Alan M., Brown, Alastair J. H., Butler, Hayley S., Boyd, Scott, Butlin, Roger J., Chappell, Ben, Clarkson, Paul, Collins, Shelley, Davies, Rober

Journal:

Journal of Medicinal Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 1.28 MB

english, 2017

28

Discovery of Pyrazolo[1,5- a ]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors

McCoull, William, Abrams, Roman D., Anderson, Erica, Blades, Kevin, Barton, Peter, Box, Matthew, Burgess, Jonathan, Byth, Kate, Cao, Qing, Chuaqui, Claudio, Carbajo, Rodrigo J., Cheung, Tony, Code, Er

Journal:

Journal of Medicinal Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 4.02 MB

english, 2017

29

Correction to Discovery of Pyrazolo[1,5- a ]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors

McCoull, William, Abrams, Roman D., Anderson, Erica, Blades, Kevin, Barton, Peter, Box, Matthew, Burgess, Jonathan, Byth, Kate, Cao, Qing, Chuaqui, Claudio, Carbajo, Rodrigo J., Cheung, Tony, Code, Er

Journal:

Journal of Medicinal Chemistry

Année:

2017

Fichier:

PDF, 170 KB

2017

30

The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1

Sundström, Linda, Myhre, Susanna, Sundqvist, Monika, Ahnmark, Andrea, McCoull, William, Raubo, Piotr, Groombridge, Sam D., Polla, Magnus, Nyström, Ann-Christin, Kristensson, Lisbeth, Någård, Mats, Win

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 4.57 MB

english, 2017

31

Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6

McCoull, William, Cheung, Tony, Anderson, Erica, Barton, Peter, Burgess, Jonathan, Byth, Kate, Cao, Qing, Castaldi, M. Paola, Chen, Huawei, Chiarparin, Elisabetta, Carbajo, Rodrigo J., Code, Erin, Cow

Journal:

ACS Chemical Biology

Année:

2018

Langue:

english

Fichier:

PDF, 6.05 MB

english, 2018

32

Free Ligand 1D NMR Conformational Signatures to Enhance Structure Based Drug Design of a Mcl-1 inhibitor (AZD5991) and other Synthetic Macrocycles

Balazs, Amber Y S, Carbajo, Rodrigo J., Davies, Nichola L, Dong, Yu, Hird, Alexander W, Johannes, Jeffrey W., Lamb, Michelle L, McCoull, William, Raubo, Piotr, Robb, Graeme R., Packer, Martin J, Chiar

Journal:

Journal of Medicinal Chemistry

Année:

2019

Langue:

english

Fichier:

PDF, 1.17 MB

english, 2019